Orang’o, Elkanah O.Emont, Jordan P.Ermel, Aaron C.Liu, TaoOmodi, VictorTong, YanItsura, Peter M.Tonui, Philip K.Maina, TitusOng’echa, John M.Muthoka, KaptenKiptoo, StephenMoormann, AnnHogan, JosephLoehrer, Patrick J.Brown, DarronCu-Uvin, Susan2023-04-062023-04-062020-11Orang'o EO, Emont JP, Ermel AC, et al. Detection of types of HPV among HIV-infected and HIV-uninfected Kenyan women undergoing cryotherapy or loop electrosurgical excision procedure. Int J Gynaecol Obstet. 2020;151(2):279-286. doi:10.1002/ijgo.13330https://hdl.handle.net/1805/32269Objective: To assess the baseline types of HPV infection among HIV-positive and HIV-negative women in western Kenya undergoing cryotherapy or loop electrosurgical excision procedure (LEEP) for cervical intraepithelial neoplasia. Methods: A prospective observational study was conducted of baseline HPV characteristics of women undergoing visual inspection with acetic acid (VIA) and cryotherapy or LEEP. After a positive VIA in HIV-positive and HIV-negative women, data on demographics, CD4 count, and use of antiretroviral therapy and a cervical swab were collected. HPV typing was performed using the Roche Linear Array. Results: Of 175 participants, 86 (49.1%) were HIV-positive and had a higher prevalence of low-risk HPV types (odds ratio [OR] 5.28, P=0.005) compared with HIV-negative women. The most common high-risk (HR)-HPV types in HIV-positive women were HPV 16 (13.9%) and HPV 18 (11.1%). HIV-positive women requiring LEEP were more likely to have HR-HPV types (OR 6.67, P=0.012) and to be infected with multiple HR-HPV types (OR 7.79, P=0.024) compared to those undergoing cryotherapy. Conclusion: HIV-positive women requiring LEEP versus cryotherapy had a higher prevalence of any HR-HPV type and multiple HR-HPV types. There were no such differences in HPV types identified among HIV-negative women.en-USPublisher PolicyCryotherapyElectrosurgeryHIV infectionsKenyaPapillomavirus infectionsUterine cervical dysplasiaArticle