Jain, RahulBarmeda, MamtaJain, RohitShirazi, JonathanMiller, John M.2022-05-192022-05-192021Jain R, Barmeda M, Jain R, Shirazi J, Miller JM. Mechanical suppression of premature ventricular complexes during catheter ablation procedures. Indian Pacing Electrophysiol J. 2021;21(1):29-35. doi:10.1016/j.ipej.2020.11.017https://hdl.handle.net/1805/29065Introduction: Mechanical suppression of premature ventricular complexes (PVCs) is not a well-known observation. We retrospectively reviewed this phenomenon in the Ventricular Arrhythmia (VA) ablation procedures performed at Richard L. Roudebush Veterans Health Administration (VHA) center. Methods: Data from 40 consecutive patients who underwent VA ablation at VHA, Indianapolis, IN, with 44 VA was included in the study. Demographic and electrophysiological parameter data was collected. Results: Overall the mean age of the population was 64 ± 11 years. The phenomenon of mechanical suppression was seen in 11 PVCs. The mean age was 59 ± 15 years in the group in which mechanical suppression was seen. Of the 11 cases, the site of earliest activation was seen in the coronary sinus in 8 and in the pulmonary artery in 3. In one case catheter ablation was not performed because of proximity to the left coronary artery system. However, sustained pressure at the site with earliest electrograms (-35 ms) and 95% pacematch resulted in long-term suppression of PVCs. In the cases in which mechanical suppression was seen, there was a statistically significant reduction in PVC burden compared to pre ablation PVC load (1.1% ± 1.50% (post ablation) versus 24.04% ± 13.07% (pre ablation) versus p < 0.05). In all the 11 cases the site of mechanical suppression was also the site with earliest electrograms. Conclusion: This case series illustrates phenomenon of mechanical suppression of PVCs as an indication for good site for successful ablation in unique veteran patient population.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalPremature ventricular complexVentricular arrhythmiasRadiofrequency ablationMechanical suppressionArticle