Prabhu, LakshmiMundade, RasikaKorc, MurrayLoehrer, Patrick J.Lu, Tao2016-06-302016-06-302014-11-30Prabhu, L., Mundade, R., Korc, M., Loehrer, P. J., & Lu, T. (2014). Critical role of NF-κB in pancreatic cancer. Oncotarget, 5(22), 10969–10975.https://hdl.handle.net/1805/10278Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, and in spite of intense efforts there are limited therapeutic options for patients with PDAC. PDACs harbor a high frequency of Kras mutations and other driver mutations that lead to altered signaling pathways and contribute to therapeutic resistance. Importantly, constitutive activation of nuclear factor κB (NF-κB) is frequently observed in PDAC. An increasing body of evidence suggests that both classical and non-classical NF-κB pathways play a crucial role in PDAC development and progression. In this review, we update the most recent advances regarding different aspects of NF-κB involvement in PDAC development and progression, emphasizing its potential as a therapeutic target and the need to discover pathway-specific cytosolic NF-κB regulators which could be used to design novel therapeutic strategies for PDAC.Attribution-NonCommercial-NoDerivs 3.0 United StatesNF-κBPancreatic cancerArticle