Ugai, TomotakaHaruki, KoichiroVäyrynen, Juha P.Borowsky, JenniferFujiyoshi, KenjiLau, Mai ChanAkimoto, NaohikoZhong, RongKishikawa, JunkoArima, KotaShi, Shan-shanZhao, MelissaFuchs, Charles S.Zhang, XuehongGiannakis, MariosSong, MingyangNan, HongmeiMeyerhardt, Jeffrey A.Wang, MolinNowak, Jonathan A.Ogino, Shuji2024-04-302024-04-302022Ugai T, Haruki K, Väyrynen JP, et al. Coffee Intake of Colorectal Cancer Patients and Prognosis According to Histopathologic Lymphocytic Reaction and T-Cell Infiltrates. Mayo Clin Proc. 2022;97(1):124-133. doi:10.1016/j.mayocp.2021.09.007https://hdl.handle.net/1805/40348Given previous biological evidence of immunomodulatory effects of coffee, we hypothesized that the association between coffee intake of colorectal cancer patients and survival differs by immune responses. Using a molecular pathological epidemiology database of 4,465 incident colorectal cancer cases, including 1,262 cases with molecular data, in the Nurses’ Health Study and the Health Professionals Follow-up Study, we examined the association between coffee intake of colorectal cancer patients and survival in strata of levels of histopathologic lymphocytic reaction and T-cell infiltrates in tumor tissue. We did not observe a significant association of coffee intake with colorectal cancer-specific mortality [multivariable-adjusted hazard ratio (HR) for one cup increase of coffee intake per day, 0.93; 95% confidence interval (CI), 0.84-1.03]. Although statistical significance was not reached at the stringent level (α=0.005), the association of coffee intake with colorectal cancer-specific mortality differed by Crohn's-like lymphoid reaction (Pinteraction=.007). Coffee intake was associated with lower colorectal cancer-specific mortality in patients with high Crohn's-like reaction (multivariable HR for one cup increase of coffee intake per day, 0.55; 95% CI, 0.37–0.81; Ptrend=.002), but not in patients with intermediate Crohn's-like reaction (the corresponding HR, 1.02; 95% CI, 0.72–1.44) or negative/low Crohn's-like reaction (the corresponding HR, 0.95; 95% CI, 0.83–1.07). The associations of coffee intake with colorectal cancer-specific mortality did not significantly differ by levels of other lymphocytic reaction or any T-cell subset (Pinteraction>.18). There is suggestive evidence for differential prognostic effects of coffee intake by Crohn’s-like lymphoid reaction in colorectal cancer.en-USPublisher PolicyColorectal neoplasmsBeverageImmunofluorescenceTumor microenvironmentArticle