Lee, BitBasavarajappa, Halesha D.Sulaiman, Rania S.Fei, XiangSeo, Seung-YongCorson, Timothy W.2015-06-302015-06-302014Lee, B., Basavarajappa, H. D., Sulaiman, R. S., Fei, X., Seo, S. Y., & Corson, T. W. (2014). The first synthesis of the antiangiogenic homoisoflavanone, cremastranone. Organic & biomolecular chemistry, 12(39), 7673-7677.https://hdl.handle.net/1805/6513An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis.en-USantiangiogenic homoisoflavanonecremastranoneArticle