Khanna, RajeshWilson, Sarah M.Brittain, Joel M.Weimer, JillSultana, RukhsanaButterfield, AllanHensley, Kenneth2025-05-282025-05-282012Khanna R, Wilson SM, Brittain JM, et al. Opening Pandora's jar: a primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders. Future Neurol. 2012;7(6):749-771. doi:10.2217/FNL.12.68https://hdl.handle.net/1805/48425CRMP2, also known as DPYSL2/DRP2, Unc-33, Ulip or TUC2, is a cytosolic phosphoprotein that mediates axon/dendrite specification and axonal growth. Mapping the CRMP2 interactome has revealed previously unappreciated functions subserved by this protein. Together with its canonical roles in neurite growth and retraction and kinesin-dependent axonal transport, it is now known that CRMP2 interacts with numerous binding partners to affect microtubule dynamics; protein endocytosis and vesicular cycling, synaptic assembly, calcium channel regulation and neurotransmitter release. CRMP2 signaling is regulated by post-translational modifications, including glycosylation, oxidation, proteolysis and phosphorylation; the latter being a fulcrum of CRMP2 functions. Here, the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders are discussed and evidence is presented for therapeutic strategies targeting CRMP2 functions.en-USPublisher PolicyAlzheimer’s diseaseAmyotrophic lateral sclerosisAxon elongationExcitotoxicityMultiple sclerosisNeuropathic painOxidative damageArticle