Wannemuehler, Todd J.Hubbell, Richard D.Nelson, Rick F.2017-06-022017-06-022016-10Wannemuehler, T. J., Hubbell, R. D., & Nelson, R. F. (2016). Tension Pneumocephalus Related to Spontaneous Skull Base Dehiscence in a Patient on BiPAP. Otology & Neurotology, 37(9), e322–e324. https://doi.org/10.1097/MAO.0000000000001141https://hdl.handle.net/1805/12820Spontaneous pneumocephalus is an uncommon phenomenon that may develop in patients with occult skull base defects. There have been reports of pneumocephalus occurring spontaneously in the setting of continuous positive airway pressure (CPAP) use (1). Tension pneumocephalus represents a neurosurgical emergency where intracranial air is trapped with increasing pressures resulting in neurological deterioration (2). Previous literature has also documented the growing understanding of how obesity, elevated intracranial pressure (ICP), obstructive sleep apnea (OSA), and cortical skull thinning are associated with spontaneous tegmen dehiscence and cerebrospinal fluid (CSF) leakage (3). Other mechanisms for spontaneous CSF leak include aberrant arachnoid granulation, congenital skull base dehiscences, increased abdominal and thoracic pressure resulting in reduced cerebral venous drainage, and age-related cortical thinning. In this report, we present the case of a bilevel positive airway pressure (BiPAP) user with an undiagnosed spontaneous tegmen dehiscence who developed spontaneous tension pneumocephalus.enPublisher Policyspontaneous pneumocephalusoccult skull base defectstension pneumocephalusArticle