Chumin, Evgeny J.Risacher, Shannon L.West, John D.Apostolova, Liana G.Farlow, Martin R.McDonald, Brenna C.Wu, Yu-ChienSaykin, Andrew J.Sporns, Olaf2022-12-212022-12-212021Chumin EJ, Risacher SL, West JD, et al. Temporal stability of the ventral attention network and general cognition along the Alzheimer's disease spectrum. Neuroimage Clin. 2021;31:102726. doi:10.1016/j.nicl.2021.102726https://hdl.handle.net/1805/30783Understanding the interrelationships of clinical manifestations of Alzheimer’s disease (AD) and functional connectivity (FC) as the disease progresses is necessary for use of FC as a potential neuroimaging biomarker. Degradation of resting-state networks in AD has been observed when FC is estimated over the entire scan, however, the temporal dynamics of these networks are less studied. We implemented a novel approach to investigate the modular structure of static (sFC) and time-varying (tvFC) connectivity along the AD spectrum in a two-sample Discovery/Validation design (n = 80 and 81, respectively). Cortical FC networks were estimated across 4 diagnostic groups (cognitively normal, subjective cognitive decline, mild cognitive impairment, and AD) for whole scan (sFC) and with sliding window correlation (tvFC). Modularity quality (across a range of spatial scales) did not differ in either sFC or tvFC. For tvFC, group differences in temporal stability within and between multiple resting state networks were observed; however, these differences were not consistent between samples. Correlation analyses identified a relationship between global cognition and temporal stability of the ventral attention network, which was reproduced in both samples. While the ventral attention system has been predominantly studied in task-evoked designs, the relationship between its intrinsic dynamics at-rest and general cognition along the AD spectrum highlights its relevance regarding clinical manifestation of the disease.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalAlzheimer’s diseaseFunctional connectivityDynamic connectivityModularityNetworksArticle