Kokurewicz, K.Brunetti, E.Welsh, G. H.Wiggins, S. M.Boyd, M.Sorensen, A.Chalmers, A. J.Schettino, G.Subiel, A.DesRosiers, C.Jaroszynski, D. A.2020-07-312020-07-312019Kokurewicz, K., Brunetti, E., Welsh, G. H., Wiggins, S. M., Boyd, M., Sorensen, A., Chalmers, A. J., Schettino, G., Subiel, A., DesRosiers, C., & Jaroszynski, D. A. (2019). Focused very high-energy electron beams as a novel radiotherapy modality for producing high-dose volumetric elements. Scientific Reports, 9(1), 10837. https://doi.org/10.1038/s41598-019-46630-whttps://hdl.handle.net/1805/23511The increased inertia of very high-energy electrons (VHEEs) due to relativistic effects reduces scattering and enables irradiation of deep-seated tumours. However, entrance and exit doses are high for collimated or diverging beams. Here, we perform a study based on Monte Carlo simulations of focused VHEE beams in a water phantom, showing that dose can be concentrated into a small, well-defined volumetric element, which can be shaped or scanned to treat deep-seated tumours. The dose to surrounding tissue is distributed over a larger volume, which reduces peak surface and exit doses for a single beam by more than one order of magnitude compared with a collimated beam.enAttribution 4.0 Internationalvery high-energy electronshigh-dose volumetric elementsradiotherapy modalityArticle