Yen, HsuanYen, HsiDrucker, Aaron M.Han, JialiLi, Wen-QingLi, TriciaQureshi, AbrarCho, Eunyoung2024-04-302024-04-302022Yen H, Yen H, Drucker AM, et al. COX-2 inhibitors show no preventive effect in the development of skin cancer. J Dtsch Dermatol Ges. 2022;20(2):157-166. doi:10.1111/ddg.14649https://hdl.handle.net/1805/40374Background: Some clinical trials found that cyclooxygenase-2 (COX-2) inhibitor use lowered the risk of skin cancer in high-risk groups. Patients and methods: To determine whether COX-2 inhibitor use is associated with lower risk of basal cell carcinoma (BCC), cutaneous squamous cell carcinoma (cSCC), and melanoma, we analyzed COX-2 inhibitor use and risk of skin cancer based on three prospective cohort studies, the Nurses' Health Study (NHS), NHS II, and the Health Professionals Follow-up Study, including 153,882 participants. Multivariable hazard ratios (HRs) and 95 % confidence intervals (CIs) for the association of COX-2 inhibitor use with risk of BCC, cSCC, and melanoma were estimated using Cox proportional hazards models. We pooled the results using a fixed effects model. Results: 16,142 BCC, 1,973 cSCC, and 631 melanoma cases were documented. Ever vs. never use of COX-2 inhibitor was associated with a modestly increased risk of BCC (multivariable HR 1.09, 95 % CI 1.05-1.14). The hazard ratio was similar for cSCC (multivariable HR 1.12, 95 % CI 1.00-1.27) and melanoma (multivariable HR 1.10, 95 % CI 0.89-1.38), but was not statistically significant. Conclusions: Ever use of COX-2 inhibitor was not associated with a decreased skin cancer risk but was instead associated with a modest, increased risk of BCC.en-USPublisher PolicyBasal cell carcinomaSquamous cell carcinomaCyclooxygenase 2 inhibitorsSkin neoplasmsArticle