Rolle-McFarland, DanelleLiu, YingziMostafaei, FarshadZauber, S. ElizabethZhou, YuanzhongLi, YanFan, QuiyanZheng, WeiNie, Linda H.Wells, Ellen M.2020-07-212020-07-212019-05-20Rolle-McFarland, D., Liu, Y., Mostafaei, F., Zauber, S. E., Zhou, Y., Li, Y., Fan, Q., Zheng, W., Nie, L. H., & Wells, E. M. (2019). The association of bone, fingernail and blood manganese with cognitive and olfactory function in Chinese workers. The Science of the total environment, 666, 1003–1010. https://doi.org/10.1016/j.scitotenv.2019.02.208https://hdl.handle.net/1805/23313Occupational manganese (Mn) exposure has been associated with cognitive and olfactory dysfunction; however, few studies have incorporated cumulative biomarkers of Mn exposure such as bone Mn (BnMn). Our goal was to assess the cross-sectional association between BnMn, blood Mn (BMn), and fingernail Mn (FMn) with cognitive and olfactory function among Mn-exposed workers. A transportable in vivo neutron activation analysis (IVNAA) system was designed and utilized to assess BnMn among 60 Chinese workers. BMn and FMn were measured using inductively coupled plasma mass spectrometry. Cognitive and olfactory function was assessed using Animal and Fruit Naming tests, World Health Organization/University of California-Los Angeles Auditory Verbal Learning Test (AVLT) and the University of Pennsylvania Smell Identification Test (UPSIT). Additional data were obtained via questionnaire. Regression models adjusted for age, education, factory of employment, and smoking status (UPSIT only), were used to assess the relationship between Mn biomarkers and test scores. In adjusted models, increasing BnMn was significantly associated with decreased performance on average AVLT scores [β (95% confidence interval (CI)) = -0.65 (-1.21, -0.09)] and Animal Naming scores [β (95% CI) = -1.54 (-3.00, -0.07)]. Increasing FMn was significantly associated with reduced performance measured by the average AVLT [β (95% CI) = -0.35 (-0.70, -0.006)] and the difference in AVLT scores [β (95% CI) = -0.40 (-0.77, -0.03)]. BMn was not significantly associated with any test scores; no significant associations were observed with Fruit Naming or UPSIT tests. BnMn and FMn, but not BMn, are associated with cognitive function in Mn-exposed workers. None of theen-USPublisher PolicyManganeseCognitive functionOlfactory functionBiomarkerNeutron activation analysisArticle