Wu, XuesongZhao, YanGe, Haibo2015-09-032015-09-032015-03Wu, X., Zhao, Y., & Ge, H. (2015). Direct Aerobic Carbonylation of C (sp2)–H and C (sp3)–H Bonds through Ni/Cu Synergistic Catalysis with DMF as the Carbonyl Source. Journal of the American Chemical Society, 137(15), 4924-4927.https://hdl.handle.net/1805/6737The direct carbonylation of aromatic sp2 and unactivated sp3 C–H bonds of amides was achieved via nickel/copper catalysis under atmospheric O2 with the assistance of a bidentate directing group. The sp2 C–H functionalization showed high regioselectivity and good functional group compatibility. The sp3 C–H functionalization showed high site-selectivity by favoring the C–H bonds of α-methyl groups over those of the α-methylene, β- or γ-methyl groups. Moreover, this reaction showed a predominant preference for functionalizing the α-methyl over α-phenyl group. Mechanistic studies revealed that nickel/copper synergistic catalysis is involved in this process.en-USPublisher Policydirect carbonylationnickel/copper catalysisArticle