Wang, HongjianLv, KaiLi, XiaoningWang, BoWang, ApengTao, ZeyuGeng, YunheWang, BinHuang, MenghaoLiu, MingliangGuo, HuiyuanLu, Yu2018-09-282018-09-282018Wang, H., Lv, K., Li, X., Wang, B., Wang, A., Tao, Z., ... & Guo, H. (2018). Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives. Chinese Chemical Letters. https://doi.org/10.1016/j.cclet.2018.08.005https://hdl.handle.net/1805/17417We report herein the design and synthesis of a series of novel nitrobenzamide derivatives. Results reveal that many of them display considerable in vitro antitubercular activity. Four N-benzyl or N-(pyridine-2-yl)methyl 3,5-dinitrobenzamides A6, A11, C1 and C4 have not only the same excellent MIC values of <0.016 μg/mL against both drug-sensitive MTB strain H37Rv and two drug-resistant clinical isolates as PBTZ169 and the lead 1, but also acceptable safety indices (SI > 1500), opening a new direction for further development.enPublisher Policynitrobenzamidessynthesisantimycobacterial activityArticle