Foley, JohnNickerson, NicoleRiese, David J., IIHollenhorst, Peter C.Lorch, GwendolenFoley, Anne M.2025-07-012025-07-012012Foley J, Nickerson N, Riese DJ 2nd, Hollenhorst PC, Lorch G, Foley AM. At the crossroads: EGFR and PTHrP signaling in cancer-mediated diseases of bone. Odontology. 2012;100(2):109-129. doi:10.1007/s10266-012-0070-5https://hdl.handle.net/1805/49117The epidermal growth factor receptor is a well-established cancer therapeutic target due to its stimulation of proliferation, motility, and resistance to apoptosis. Recently, additional roles for the receptor have been identified in growth of metastases. Similar to development, metastatic spread requires signaling interactions between epithelial-derived tumor cells and mesenchymal derivatives of the microenvironment. This necessitates reactivation of developmental signaling molecules, including the hypercalcemia factor parathyroid hormone-related protein. This review covers the variations of epidermal growth factor receptor signaling in cancers that produce bone metastases, regulation of parathyroid hormone-related protein, and evidence that the two molecules drive cancer-mediated diseases of bone.en-USPublisher PolicyPTHrPEGFRGene expressionSquamous cell carcinomaBone metastasisHypercalcemiaArticle