Maupin, Kevin A.Childress, PaulBrinker, AlexanderKhan, FaisalAbeysekera, IrushiAguilar, Izath NizeetOlivos, David J., IIIAdam, GremahSavaglio, Michael K.Ganesh, VenkateswaranGorden, RileyMannfeld, RachelBeckner, ElliottHoran, Daniel J.Robling, Alexander G.Chakraborty, NabarunGautam, AartiHammamieh, RashaKacena, Melissa A.2020-01-162020-01-162019-09-24Maupin, K. A., Childress, P., Brinker, A., Khan, F., Abeysekera, I., Aguilar, I. N., … Kacena, M. A. (2019). Skeletal adaptations in young male mice after 4 weeks aboard the International Space Station. NPJ microgravity, 5, 21. doi:10.1038/s41526-019-0081-4https://hdl.handle.net/1805/21864Gravity has an important role in both the development and maintenance of bone mass. This is most evident in the rapid and intense bone loss observed in both humans and animals exposed to extended periods of microgravity in spaceflight. Here, cohabitating 9-week-old male C57BL/6 mice resided in spaceflight for ~4 weeks. A skeletal survey of these mice was compared to both habitat matched ground controls to determine the effects of microgravity and baseline samples in order to determine the effects of skeletal maturation on the resulting phenotype. We hypothesized that weight-bearing bones would experience an accelerated loss of bone mass compared to non-weight-bearing bones, and that spaceflight would also inhibit skeletal maturation in male mice. As expected, spaceflight had major negative effects on trabecular bone mass of the following weight-bearing bones: femur, tibia, and vertebrae. Interestingly, as opposed to the bone loss traditionally characterized for most weight-bearing skeletal compartments, the effects of spaceflight on the ribs and sternum resembled a failure to accumulate bone mass. Our study further adds to the insight that gravity has site-specific influences on the skeleton.en-USAttribution 4.0 InternationalTranslational researchAnatomyArticle