Ahmad, JawadOdin, Joseph A.Hayashi, Paul H.Fontana, Robert J.Conjeevaram, HariAvula, BharathiKhan, Ikhlas A.Barnhart, HuimanVuppalanchi, RajNavarro, Victor J.Drug-Induced Liver Injury Network2023-05-012023-05-012021Ahmad J, Odin JA, Hayashi PH, et al. Liver injury associated with kratom, a popular opioid-like product: Experience from the U.S. drug induced liver injury network and a review of the literature. Drug Alcohol Depend. 2021;218:108426. doi:10.1016/j.drugalcdep.2020.108426https://hdl.handle.net/1805/32728Background: Kratom is a botanical product used as an opium substitute with abuse potential. Methods: Assessment of suspected cases of kratom-induced liver injury in a prospective US cohort. Results: Eleven cases of liver injury attributed to kratom were identified with a recent increase. The majority were male with median age 40 years. All were symptomatic and developed jaundice with a median latency of 14 days. The liver injury pattern was variable, most required hospitalization and all eventually recovered. Biochemical analysis revealed active kratom ingredients. Conclusion: Kratom can cause severe liver injury with jaundice.en-USPublisher PolicyKratomHepatotoxicityMitragynine7-hydroxymitragynineOpioidArticle