McDaniel, Jodi C.Rausch, JamieTan, Alai2022-02-182022-02-182020-01-16McDaniel, J. C., Rausch, J., & Tan, A. (2020). Impact of omega-3 fatty acid oral therapy on healing of chronic venous leg ulcers in older adults: Study protocol for a randomized controlled single-center trial. Trials, 21(1), 93. https://doi.org/10.1186/s13063-019-3970-71745-6215https://hdl.handle.net/1805/27851This trial addresses the global problem of chronic venous leg ulcers (CVLUs), wounds that cause significant infirmity for an estimated 9.7 million people annually, mainly older adults with comorbidities. Advanced therapies are needed because standard topical therapies are often ineffective or yield only short-term wound healing. Thus, we are testing a new oral therapy containing the bioactive elements of fish oil, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for targeting and reducing the high numbers of activated polymorphonuclear leukocytes (PMN) in wound microenvironments that keep CVLUs “trapped” in a chronic inflammatory state.enAttribution 4.0 United StatesFatty acidsFish OilVenous leg ulcersArticle