Scott, William L.Zhou, ZiniuZajdel, PawelPawlowski, MaciejO'Donnell, Martin J.2019-06-052019-06-052010-07-20Scott, W. L., Zhou, Z., Zajdel, P., Pawłowski, M., & O'Donnell, M. J. (2010). Solid-phase synthetic route to multiple derivatives of a fundamental peptide unit. Molecules (Basel, Switzerland), 15(7), 4961–4983. doi:10.3390/molecules15074961https://hdl.handle.net/1805/19540Amino acids are Nature's combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all peptides and proteins. We report a solid-phase synthetic route to large combinatorial variations of this fundamental scaffold, extending the variety of substituted biomimetic molecules available to successfully implement the Distributed Drug Discovery (D3) project. In a single solid-phase sequence, compatible with basic amine substituents, three-point variation is performed at the amino acid a-carbon and the amino and carboxyl functionalities.en-USAttribution-NonCommercial-NoDerivs 3.0 United StatesDistributed Drug Discovery (D3)Fundamental peptide scaffoldBiomimeticsSolid-phase organic synthesisCombinatorial chemistryArticle