Lazzara, Joseph T.Arthur, Lachlan W.Jenkins, CathyDodd, Christopher A. F.Mellon, Stephen J.Murray, David W.2025-04-252025-04-252023-09-28Lazzara JT, Arthur LW, Jenkins C, Dodd CAF, Mellon SJ, Murray DW. Fixed lateral unicompartmental knee replacement is a reliable treatment for lateral compartment osteoarthritis after mobile-bearing medial unicompartmental replacement. Knee Surg Sports Traumatol Arthrosc. 2023 Dec;31(12):5407-5412. doi: 10.1007/s00167-023-07573-y. Epub 2023 Sep 28. PMID: 37768357; PMCID: PMC10719134.https://hdl.handle.net/1805/47472Purpose: Lateral osteoarthritis following medial unicompartmental knee replacement (UKR) is usually treated with total knee replacement, however, lateral UKR is a less invasive option that preserves a well-functioning medial UKR. This study aimed to determine the 5-year outcome of the cemented Fixed Lateral Oxford UKR (FLO) when used for the treatment of severe lateral disease after medial Oxford unicompartmental knee replacement. Methods: Forty-four knees with lateral bone-on-bone osteoarthritis (n = 43) and avascular necrosis (n = 1) treated with the FLO following medial Oxford UKR were followed up prospectively. The Oxford Knee Score (OKS) and Tegner Activity Score (TAS) were collected pre- and post-operatively. Life-table analysis was used to determine survival rates. Results: The mean patient age at the time of FLO surgery was 74.4 years with a mean time of 12.1 years between the primary medial UKR and the conversion to a bi-UKR with a FLO. Mean follow-up of the FLO was 3.5 years. After FLO no intra-operative or medical complications, re-admissions, or mortality occurred. There was one reoperation in which a bearing was exchanged for a medial bearing dislocation. There were no revisions of the FLO, so the FLO survival rate at 5 years was 100% (24 at risk). The mean pre-operative OKS was 22, which significantly (p < 0.0001) improved to a mean of 42, 42, and 40 at 1, 2, and 5 years, respectively. The median TAS had a non-significant improvement from 2.5 (Range 0-8) pre-operatively to 2 (Range 1-6) at 5 years postoperatively. Conclusion: The FLO is a reliable treatment for lateral osteoarthritis following medial UKR. At 5 years there was a 100% survival of the FLO with a mean OKS of 40.en-USAttribution 4.0 InternationalAgedKnee Replacement ArthroplastyKnee ProsthesisLysholm Knee ScoreKnee OsteoarthritisReoperationTreatment OutcomeArticle