Jakeman, Steven A.Henry, Courtney N.Martin, Berdine R.McCabe, George P.McCabe, Linda D.Jackson, George S.Peacock, MunroWeaver, Connie M.2017-04-202017-04-202016Jakeman, S. A., Henry, C. N., Martin, B. R., McCabe, G. P., McCabe, L. D., Jackson, G. S., … Weaver, C. M. (2016). Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner: a randomized crossover trial. The American Journal of Clinical Nutrition, 104(3), 837–843. https://doi.org/10.3945/ajcn.116.132761https://hdl.handle.net/1805/12278Background: Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adolescents and the bone strength and architecture in rodent models. Objective: In this study, we aimed to determine the skeletal benefits of SCF in postmenopausal women. Design: We used our novel technology of determining bone calcium retention by following the urinary appearance of 41Ca, a rare long-lived radioisotope, from prelabeled bone to rapidly and sensitively evaluate the effectiveness of SCF in reducing bone loss. A randomized-order, crossover, double-blinded trial was performed in 14 healthy postmenopausal women to compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d. Results: A dose-response effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.8% (P < 0.05) and 7% (P < 0.04), respectively. The bone turnover biomarkers N-terminal telopeptide and osteocalcin were not changed by the interventions; however, a significant increase in bone-specific alkaline phosphatase, which is a bone-formation marker, was detected between 0 and 20 g fiber from SCF/d (8%; P = 0.035). Conclusion: Daily SCF consumption significantly increased bone calcium retention in postmenopausal women, which improved the bone calcium balance by an estimated 50 mg/d. This study was registered at clinicaltrials.gov as NCT02416947.enPublisher Policybone calcium retentionbone-specific alkaline phosphatasepostmenopausal womenArticle