Vreeman, Rachel C.Nyandiko, Winstone M.Liu, HaiTu, WanzhuScanlon, Michael L.Slaven, James E.Ayaya, Samuel O.Inui, Thomas S.2016-07-272016-07-272015-04Vreeman, R. C., Nyandiko, W. M., Liu, H., Tu, W., Scanlon, M. L., Slaven, J. E., … Inui, T. S. (2015). Comprehensive Evaluation of Caregiver-Reported Antiretroviral Therapy Adherence for HIV-Infected Children. AIDS and Behavior, 19(4), 626–634. http://doi.org/10.1007/s10461-015-0998-x1573-3254https://hdl.handle.net/1805/10494For HIV-infected children, adherence to antiretroviral therapy (ART) is often assessed by caregiver report but there are few data on their validity. We conducted prospective evaluations with 191 children ages 0-14 years and their caregivers over 6 months in western Kenya to identify questionnaire items that best predicted adherence to ART. Medication Event Monitoring Systems(®) (MEMS, MWV/AARDEX Ltd., Switzerland) electronic dose monitors were used as external criterion for adherence. We employed a novel variable selection tool using the LASSO technique with logistic regression to identify items best correlated with dichotomized MEMS adherence (≥90 or <90 % doses taken). Nine of 48 adherence items were identified as the best predictors of adherence, including missed or late doses in the past 7 days, problems giving the child medicines, and caregiver-level factors like not being present at medication taking. These items could be included in adherence assessment tools for pediatric patients.en-USPublisher PolicyAnti-HIV Agentstherapeutic usecaregiversHIV Infectionsdrug therapyMedication Adherencestatistics & numerical dataParentsArticle