Zhang, NanhuaLiu, ChunyanSteiner, Steven J.Colletti, Richard B.Baldassano, RobertChen, ShiranCohen, StanleyKappelman, Michael D.Saeed, ShehzadConklin, Laurie S.Strauss, RichardVolger, SheriKing, EileenLo, Kim Hung2024-02-262024-02-262023Zhang N, Liu C, Steiner SJ, et al. Using multiple imputation of real-world data to estimate clinical remission in pediatric inflammatory bowel disease. J Comp Eff Res. 2023;12(4):e220136. doi:10.57264/cer-2022-0136https://hdl.handle.net/1805/38649Aims: To evaluate the performance of the multiple imputation (MI) method for estimating clinical effectiveness in pediatric Crohn's disease in the ImproveCareNow registry; to address the analytical challenge of missing data. Materials & methods: Simulation studies were performed by creating missing datasets based on fully observed data from patients with moderate-to-severe Crohn's disease treated with non-ustekinumab biologics. MI was used to impute sPCDAI remission statuses in each simulated dataset. Results: The true remission rate (75.1% [95% CI: 72.6%, 77.5%]) was underestimated without imputation (72.6% [71.8%, 73.3%]). With MI, the estimate was 74.8% (74.4%, 75.2%). Conclusion: MI reduced nonresponse bias and improved the validity, reliability, and efficiency of real-world registry data to estimate remission rate in pediatric patients with Crohn's disease.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalClinical remission statusDisease-specific patient registriesDrug repurposing and relabelingImproveCareNow registryInflammatory bowel diseaseMissing dataMultiple imputation methodPediatric Crohn's diseaseReal-world evidenceShort Pediatric Crohn's Disease Activity Index (sPCDAI)Article