Geddes, Gabrielle C.Przybylowski, Leon F., III.Ware, Stephanie M.2023-03-132023-03-132020-12Geddes GC, Przybylowski LF 3rd, Ware SM. Variants of significance: medical genetics and surgical outcomes in congenital heart disease. Curr Opin Pediatr. 2020;32(6):730-738. doi:10.1097/MOP.0000000000000949https://hdl.handle.net/1805/31842Purpose of review: This article reviews the current understanding and limitations in knowledge of the effect genetics and genetic diagnoses have on perioperative and postoperative surgical outcomes in patients with congenital heart disease (CHD). Recent findings: Presence of a known genetic diagnosis seems to effect multiple significant outcome metrics in CHD surgery including length of stay, need for extracorporeal membrane oxygenation, mortality, bleeding, and heart failure. Data regarding the effects of genetics in CHD is complicated by lack of standard genetic assessment resulting in inaccurate risk stratification of patients when analyzing data. Only 30% of variation in CHD surgical outcomes are explained by currently measured variables, with 2.5% being attributed to diagnosed genetic disorders, it is thought a significant amount of the remaining outcome variation is because of unmeasured genetic factors. Summary: Genetic diagnoses clearly have a significant effect on surgical outcomes in patients with CHD. Our current understanding is limited by lack of consistent genetic evaluation and assessment as well as evolving knowledge and discovery regarding the genetics of CHD. Standardizing genetic assessment of patients with CHD will allow for the best risk stratification and ultimate understanding of these effects.en-USPublisher PolicyCongenital heart diseaseCongenital heart surgeryGenetic testingGeneticsSurgical outcomesArticle