Duncan, Natalie A.Kronenberger, William G.Hampton, Kisha C.Bloom, Ellen M.Rampersad, Angeli G.Roberson, Christopher P.Shapiro, Amy D.2017-04-052017-04-052016Duncan, N. A., Kronenberger, W. G., Hampton, K. C., Bloom, E. M., Rampersad, A. G., Roberson, C. P., & Shapiro, A. D. (2016). A validated measure of adherence to antibiotic prophylaxis in children with sickle cell disease. Patient Preference and Adherence, 10, 983–992. http://doi.org/10.2147/PPA.S103874https://hdl.handle.net/1805/12184BACKGROUND: Antibiotic prophylaxis is a mainstay in sickle cell disease management. However, adherence is estimated at only 66%. This study aimed to develop and validate a Sickle Cell Antibiotic Adherence Level Evaluation (SCAALE) to promote systematic and detailed adherence evaluation. METHODS: A 28-item questionnaire was created, covering seven adherence areas. General Adherence Ratings from the parent and one health care provider and medication possession ratios were obtained as validation measures. RESULTS: Internal consistency was very good to excellent for the total SCAALE (α=0.89) and four of the seven subscales. Correlations between SCAALE scores and validation measures were strong for the total SCAALE and five of the seven subscales. CONCLUSION: The SCAALE provides a detailed, quantitative, multidimensional, and global measurement of adherence and can promote clinical care and research.en-USAttribution-NonCommercial 3.0 United StatesSCAALESickle SAFE Programcompliancehemoglobinopathynewborn screening programpenicillin prophylaxisArticle