Mosley, Amber L.Alakhras, Nada S.Goebl, Mark G.Hurley, Thomas D., 1961-2015-04-142015-12-022014-12https://hdl.handle.net/1805/6179http://dx.doi.org/10.7912/C2/1882Indiana University-Purdue University Indianapolis (IUPUI)In an effort to advance the methodology in analyzing RNAPII protein-protein interaction network and to determine the role of the CTD in controlling RNAPII transcription, we devised a method to specifically isolate the CTD-associated and CTD-less RNAPII to identify the proteins that interact with both the CTD and the globular core of RNAPII using novel purification scheme coupled to quantitative proteomics.en-USRNA polymerasesRNA-protein interactionsProtein-protein interactionsRetrovirusesQualitative researchThesis