Aizawa, KeikoPeltier, DanielMatsuki, EriToubai, Tomomi2025-04-112025-04-112022Aizawa K, Peltier D, Matsuki E, Toubai T. How does transfusion-associated graft-versus-host disease compare to hematopoietic cell transplantation-associated graft-versus-host disease?. Transfus Apher Sci. 2022;61(2):103405. doi:10.1016/j.transci.2022.103405https://hdl.handle.net/1805/46972Transfusion-associated graft-versus-host disease (TA-GVHD) is a rare life-threatening complication of blood transfusion caused by donor T cells that escape rejection by the recipient immune system. These donor T cells drive recipient tissue damage in response to host antigens. On the other hand, GVHD occurring after allogeneic hematopoietic cell transplantation (HCT-GVHD) is also caused by donor T cells, but its pathophysiology is more complex and differs due to the effects of tissue damage caused by pre-HCT conditioning and profound immunosuppression. Both TA-GVHD and HCT-GVHD can be fatal; however, mortality is higher with TA-GVHD due to the paucity of treatment options. Here, we compare and summarize the presentation, diagnosis, pathophysiology, prevention, and treatment of TA-GVHD and HCT-GVHD.en-USPublisher PolicyAcute GVHDAllogeneic hematopoietic cell transplantation (allo-hct)Chronic GVHDStem cell transplantation-associated graft-versus-host disease (SCT-GVHD)TransfusionTransfusion-associated graft-versus-host disease (TA-GVHD)Article