Yen, Timothy E.Allen, John C.Rivelli, Sarah K.Patterson, Stephanie C.Metcalf, Meredith R.Flink, Benjamin J.Mirrakhimov, Aibek E.Lagoo, Sandhya A.Vail, Thomas P.Young, Christopher C.Moon, Richard E.Trzepacz, Paula T.Kwatra, Madan M.2016-03-312016-03-312016Yen, T. E., Allen, J. C., Rivelli, S. K., Patterson, S. C., Metcalf, M. R., Flink, B. J., … Kwatra, M. M. (2016). Association between Serum IGF-I levels and Postoperative Delirium in Elderly Subjects Undergoing Elective Knee Arthroplasty. Scientific Reports, 6, 20736. http://doi.org/10.1038/srep207362045-2322https://hdl.handle.net/1805/9139Evidence is mixed for an association between serum insulin-like growth factor-I (IGF-I) levels and postoperative delirium (POD). The current study assessed preoperative serum IGF-I levels as a predictor of incident delirium in non-demented elderly elective knee arthroplasty patients. Preoperative serum levels of total IGF-I were measured using a commercially available Human IGF-I ELISA kit. POD incidence and severity were determined using DSM-IV criteria and the Delirium Rating Scale-Revised-98 (DRS-R98), respectively. Median IGF-I levels in delirious (62.6 ng/ml) and non-delirious groups (65.9 ng/ml) were not significantly different (p = 0.141). The ratio (95% CI) of geometric means, D/ND, was 0.86 (0.70, 1.06). The Hodges-Lehmann median difference estimate was 7.23 ng/mL with 95% confidence interval (−2.32, 19.9). In multivariate logistic regression analysis IGF-I level was not a significant predictor of incident POD after correcting for medical comorbidities. IGF-I levels did not correlate withen-USCC-BYPredictive markersTranslational researchArticle