Karnik, Sonali J.Margetts, Tyler J.Wang, Hannah S.Movila, AlexandruOblak, Adrian L.Fehrenbacher, Jill C.Kacena, Melissa A.Plotkin, Lilian I.2024-06-212024-06-212024Karnik SJ, Margetts TJ, Wang HS, et al. Mind the Gap: Unraveling the Intricate Dance Between Alzheimer's Disease and Related Dementias and Bone Health. Curr Osteoporos Rep. 2024;22(1):165-176. doi:10.1007/s11914-023-00847-xhttps://hdl.handle.net/1805/41712Purpose of review: This review examines the linked pathophysiology of Alzheimer's disease/related dementia (AD/ADRD) and bone disorders like osteoporosis. The emphasis is on "inflammaging"-a low-level inflammation common to both, and its implications in an aging population. Recent findings: Aging intensifies both ADRD and bone deterioration. Notably, ADRD patients have a heightened fracture risk, impacting morbidity and mortality, though it is uncertain if fractures worsen ADRD. Therapeutically, agents targeting inflammation pathways, especially Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and TNF-α, appear beneficial for both conditions. Additionally, treatments like Sirtuin 1 (SIRT-1), known for anti-inflammatory and neuroprotective properties, are gaining attention. The interconnectedness of AD/ADRD and bone health necessitates a unified treatment approach. By addressing shared mechanisms, we can potentially transform therapeutic strategies, enriching our understanding and refining care in our aging society. This review article is part of a series of multiple manuscripts designed to determine the utility of using artificial intelligence for writing scientific reviews.en-USAttribution 4.0 InternationalOsteoporosisAlzheimer’s diseaseFractureNeuroinflammationInflammagingEstrogenAIArtificial intelligenceChatGPTArticle