Sun, JieHe, ChaoYan, Qiu-XinWang, Hong-DanLi, Ke-XinSun, XunFeng, YanZha, Rong-RongCui, Chang-PengXiong, XueGao, ShanWang, XueYin, Rui-XueQiao, Guo-FenLi, Bai-Yan2024-03-182024-03-182021Sun J, He C, Yan QX, et al. Parkinson-like early autonomic dysfunction induced by vagal application of DOPAL in rats. CNS Neurosci Ther. 2021;27(5):540-551. doi:10.1111/cns.13589https://hdl.handle.net/1805/39313Aim: To understand why autonomic failures, a common non-motor symptom of Parkinson's disease (PD), occur earlier than typical motor disorders. Methods: Vagal application of DOPAL (3,4-dihydroxyphenylacetaldehyde) to simulate PD-like autonomic dysfunction and understand the connection between PD and cardiovascular dysfunction. Molecular and morphological approaches were employed to test the time-dependent alternation of α-synuclein aggregation and the ultrastructure changes in the heart and nodose (NG)/nucleus tractus solitarius (NTS). Results: Blood pressure (BP) and baroreflex sensitivity of DOPAL-treated rats were significantly reduced accompanied with a time-dependent change in orthostatic BP, consistent with altered echocardiography and cardiomyocyte mitochondrial ultrastructure. Notably, time-dependent and collaborated changes in Mon-/Tri-α-synuclein were paralleled with morphological alternation in the NG and NTS. Conclusion: These all demonstrate that early autonomic dysfunction mediated by vagal application of DOPAL highly suggests the plausible etiology of PD initiated from peripheral, rather than central site. It will provide a scientific basis for the prevention and early diagnosis of PD.en-USAttribution 4.0 InternationalDOPALParkinson's diseaseAutonomic dysfunctionVagusα-synucleinArticle