Williams, Justin N.Sankar, Uma2019-10-042019-10-042019-08Williams, J. N., & Sankar, U. (2019). CaMKK2 Signaling in Metabolism and Skeletal Disease: a New Axis with Therapeutic Potential. Current osteoporosis reports, 17(4), 169–177. doi:10.1007/s11914-019-00518-whttps://hdl.handle.net/1805/21058PURPOSE OF REVIEW: Age and metabolic disorders result in the accumulation of advanced glycation endproducts (AGEs), oxidative stress, and inflammation, which cumulatively cause a decline in skeletal health. Bone becomes increasingly vulnerable to fractures and its regenerative capacity diminishes under such conditions. With a rapidly aging population in the USA and the global increase in diabetes, efficacious, multi-dimensional therapies that can treat or prevent skeletal diseases associated with metabolic dysfunction and inflammatory disorders are acutely needed. RECENT FINDINGS: Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) is a key regulator of nutrient intake, glucose metabolism, insulin production, and adipogenesis. Recent studies suggest a pivotal role for CaMKK2 in bone metabolism, fracture healing, and inflammation. Aside from rekindling previous concepts of CaMKK2 as a potent regulator of whole-body energy homeostasis, this review emphasizes CaMKK2 as a potential therapeutic target to treat skeletal diseases that underlie metabolic conditions and inflammation.en-USPublisher PolicyCaMKK2DiabetesDiabetic osteopathySkeletal diseaseFracture healingArticle