Chen, LiweiLi, ShanshanHe, ChunyanZhu, YeyiBuck Louis, Germaine M.Yeung, EdwinaHu, Frank B.Zhang, Cuilin2017-08-022017-08-022016-03Chen, L., Li, S., He, C., Zhu, Y., Buck Louis, G. M., Yeung, E., … Zhang, C. (2016). Age at Menarche and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study Among 27,482 Women. Diabetes Care, 39(3), 469–471. http://doi.org/10.2337/dc15-2011https://hdl.handle.net/1805/13718OBJECTIVE: To examine the association between age at menarche and risk of gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS: A prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses' Health Study II. RESULTS: The adjusted risk ratios for GDM across the age at menarche categories (≤11, 12, 13, and ≥14 years) were 1.34 (95% CI 1.14-1.58), 1.13 (0.97-1.31), 1.11 (0.95-1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1% (P = 0.0007) of the association was mediated through prepregnancy BMI. CONCLUSIONS: These findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.en-USPublisher PolicyAdiposityDiabetes, GestationalMenarcheObesity -- ComplicationsPregnancyArticle