Kouba, ErikSimper, Novae B.Chen, ShaoxiongWilliamson, Sean R.Grignon, David J.Eble, John N.MacLennan, Gregory T.Montironi, RodolfoLopez-Beltran, AntonioOsunkoya, Adeboye O.Zhang, ShaoboWang, MingshengWang, LishaTran, ThuEmerson, Robert E.Baldridge, Lee AnnMonn, M. FrancescaLinos, KonstantinosCheng, Liang2017-09-072017-09-072017Kouba, E., Simper, N. B., Chen, S., Williamson, S. R., Grignon, D. J., Eble, J. N., … Cheng, L. (2017). Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene. Journal of Clinical Pathology, 70(6), 508–514. https://doi.org/10.1136/jclinpath-2016-204088https://hdl.handle.net/1805/14053Aims To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status. Methods The presence of the molecular hallmark NAB2-STAT6 gene fusion and for the defining fusion partner product STAT6 was assessed in 11 cases of the genitourinary tract solitary fibrous tumours. NAB2-STAT6 gene fusion analysis was performed using a break-apart fluorescence in situ hybridisation (FISH) probe using a probe cocktail with Bacterial artificial chromosome (BAC) clones for STAT6 and NAB2. Results Eleven solitary fibrous tumours were diagnosed in eight male patients and three female patients with a mean age of 46 years (range: 11–64 years). Four of the tumours had malignant histological features, and three were considered moderate risk for metastasis. With a mean follow-up time of 61 months, 1 recurred locally and 2 presented at distant metastatic sites. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion and nuclear STAT6 expression in 58% and 91% of cases, respectively. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between malignant histological features or subsequent clinical outcomes in the genitourinary solitary fibrous tumours. Conclusions A subset of solitary fibrous tumours of the genitourinary tract behaved aggressively. Using a break-apart FISH probe cocktail, we found the NAB2-STAT6 gene fusion in 64% of cases. However, the NAB2-STAT6 fusion status was not correlated with STAT6 expression or useful in discriminating between low-risk or high-risk tumours and subsequent clinical outcomes.enPublisher Policygenitourinary tract solitary fibrous tumoursNAB2-STAT6 fusion geneclinicopathological featuresArticle