Allegretti, Jessica R.Kassam, ZainOsman, MajdiBudree, ShrishFischer, MonikaKelly, Colleen R.2017-08-182017-08-182017Allegretti JR, Kassam Z, Osman M, Budree S, Fischer M, Kelly CR, The 5D Framework: A Clinical Primer for Fecal Microbiota Transplantation to Treat Clostridium difficile infection, Gastrointestinal Endoscopy (2017), Gastrointestinal Endoscopy, doi: 10.1016/j.gie.2017.05.036https://hdl.handle.net/1805/13882Clostridium difficile infection is the most common health care–associated infection in the United States. Recently, fecal microbiota transplantation (FMT) has emerged as an effective and safe therapy for recurrent C difficile infection; however, despite rapid adoption there is no standardized clinical approach. Given the rapid adoption of FMT, in part because of stool banks, there is a need for a practical primer for clinicians to safely perform FMT. Accordingly, we aim to provide a simple approach entitled the 5D FMT framework to guide physicians. The 5D FMT framework includes: decision (selecting appropriate patient for FMT), donor (selection and screening), discussion (risk, benefits, alternatives), delivery (selecting appropriate modality for FMT administration), and discharge (counseling at discharge and follow-up). We aim to help clinicians take a simple but evidence-based approach to FMT to optimize efficacy and safety. This primer navigates how to decide whether a patient with C difficile infection is appropriate for FMT and how to select and screen stool donors, identify the ideal delivery modality, and provide follow-up care after FMT.enPublisher Policyclostridium difficile infectionfecal microbiota transplantation5D FMT frameworkArticle