Bell, Richard L.Lopez, Marcelo F.Cui, ChanghaiEgli, MarkJohnson, Kirk W.Franklin, Kelle M.Becker, Howard C.2016-06-062016-06-062015-01Bell, R. L., Lopez, M. F., Cui, C., Egli, M., Johnson, K. W., Franklin, K. M., & Becker, H. C. (2015). Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence. Addiction Biology, 20(1), 38–42. http://doi.org/10.1111/adb.12106https://hdl.handle.net/1805/9775Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non-selective phosphodiesterase inhibitor, to reduce alcohol drinking and relapse in alcohol-preferring P rats, high-alcohol drinking HAD1 rats, and in mice made dependent on alcohol through cycles of alcohol vapor exposure. When administered twice daily, ibudilast reduced alcohol drinking in rats by approximately 50% and reduced drinking by alcohol-dependent mice at doses which had no effect in non-dependent mice. These findings support the viability of ibudilast as a possible treatment for alcohol dependence.Publisher PolicyAlcoholalcohol dependencealcohol preferenceAV-411MN-166Article