Carter-Bawa, LisaBanerjee, Smita C.Ostroff, Jamie S.Kale, Minal S.King, Jennifer C.Leopold, Katherine T.Monahan, Patrick O.Slaven, James E., Jr.Soylemez Wiener, RendaValenzona, FrancisRawl, Susan M.Comer, Robert Skipworth2024-01-042024-01-042023-05-04Lisa CB, Banerjee SC, Ostroff JS, et al. Leveraging social media to increase lung cancer screening awareness, knowledge and uptake among high-risk populations (The INSPIRE-Lung Study): Study protocol of design and methods of a community-based randomized controlled trial. Preprint. Res Sq. 2023;rs.3.rs-2846041. Published 2023 May 4. doi:10.21203/rs.3.rs-2846041/v1https://hdl.handle.net/1805/37619Background: Lung cancer is the leading cause of cancer death for both men and women in the United States. The National Lung Screening Trial (NLST) demonstrated that low-dose computed tomography (LDCT) screening can reduce lung cancer mortality among high-risk individuals, but uptake of lung screening remains low. Social media platforms have the potential to reach a large number of people, including those who are at high risk for lung cancer but who may not be aware of or have access to lung screening. Methods: This paper discusses the protocol for a randomized controlled trial (RCT) that leverages FBTA to reach screening-eligible individuals in the community at large and intervene with a public-facing, tailored health communication intervention (LungTalk) to increase awareness of, and knowledge about, lung screening. Discussion: This study will provide important information to inform the ability to re ne implementation processes for national population efforts to scale a public-facing health communication focused intervention using social media to increase screening uptake of appropriate, high-risk individuals.en-USAttribution 4.0 InternationalScreeningLung cancerSocial mediaDecision supportTailored communicationFacebook targeted advertisementArticle