Leung, Daniel H.Ye, WenMolleston, Jean P.Weymann, AlexanderLing, SimonParanjape, Shruti M.Romero, ReneSchwarzenberg, Sara JanePalermo, JosephAlonso, Estella M.Murray, Karen F.Marshall, Bruce C.Sherker, Averell H.Siegel, Marilyn J.Krishnamurthy, RajeshHarned, RogerKarmazyn, BoazMagee, John C.Narkewicz, Michael R.2016-12-082016-12-082015-10Leung, D. H., Ye, W., Molleston, J. P., Weymann, A., Ling, S., Paranjape, S. M., … Cystic Fibrosis Liver Disease Network (CFLD NET). (2015). Baseline Ultrasound and Clinical Correlates in Children with Cystic Fibrosis. The Journal of Pediatrics, 167(4), 862–868.e2. https://doi.org/10.1016/j.jpeds.2015.06.0620022-3476 1097-6833https://hdl.handle.net/1805/11580Objective: To investigate the relationship between abdominal ultrasound (US) findings and demographic, historical and clinical features in children with CF. Study design: Children age 3-12 years with CF without known cirrhosis, were enrolled in a prospective, multi-center study of US to predict hepatic fibrosis. Consensus US patterns were assigned by 3 radiologists as normal, heterogeneous, homogeneous, or cirrhosis. Data were derived from direct collection and U.S. or Toronto CF registries. Chi-square or ANOVA were used to compare variables among US groups and between normal and abnormal. Logistic regression was used to study risk factors for having abnormal US. Results: Findings in 719 subjects were normal (n=590, 82.1%), heterogeneous (64, 8.9%), homogeneous (41, 5.7%), and cirrhosis (24, 3.3%). Cirrhosis (p=0.0004), homogeneous (p<0.0001) and heterogeneous (p=0.03) were older than normal. More males were heterogeneous (p=0.001). More heterogeneous (15.0%, p=0.009) and cirrhosis (25.0%, p=0.005) haden-USPublisher PolicyBMI, Body mass indexCF, Cystic fibrosisCFLD, CF liver diseaseCFLD NET, Cystic Fibrosis Liver Disease NetworkFEV1, Forced expiratory volume in 1 secondNAFLD, Nonalcoholic fatty liver diseasePUSH, Prediction by Ultrasound of the Risk of Hepatic Cirrhosis in Cystic FibrosisArticle