Bakshi, RakeshGupta, KanupriyaJordan, Stephen J.Brown, Ladraka' T.Press, Christen G.Gorwitz, Rachel J.Papp, John R.Morrison, Sandra G.Lee, Jeannette Y.Morrison, Richard P.Geisler, William M.2017-12-082017-12-082017-06Bakshi, R. K., Gupta, K., Jordan, S. J., Brown, L. T., Press, C. G., Gorwitz, R. J., ... & Geisler, W. M. (2017). Immunoglobulin-Based Investigation of Spontaneous Resolution of Chlamydia trachomatis Infection. The Journal of Infectious Diseases, 215(11), 1653-1656. https://doi.org/10.1093/infdis/jix194https://hdl.handle.net/1805/14769Chlamydia trachomatis elementary body enzyme-linked immunosorbent assay (ELISA) was used to investigate serum anti-CT immunoglobulin G1 (IgG1; long-lived response) and immunoglobulin G3 (IgG3; short-lived response indicating more recent infection) from treatment (enrollment) and 6-month follow-up visits in 77 women previously classified as having spontaneous resolution of chlamydia. Of these women, 71.4% were IgG1+IgG3+, consistent with more recent chlamydia resolution. 15.6% were IgG3− at both visits, suggesting absence of recent chlamydia. Using elementary body ELISA, we demonstrated approximately 1 in 6 women classified as having spontaneous resolution of chlamydia might have been exposed to C. trachomatis but not infected. Further, we classified their possible infection stage.enIUPUI Open Access PolicychlamydiaimmunoglobulinantibodyArticle