Bhadresha, KinjalThakore, VaidehiBrahmbhatt, JpanUpadhyay, VinalJain, NayanRawal, Rakesh2024-06-072024-06-072022Bhadresha K, Thakore V, Brahmbhatt J, Upadhyay V, Jain N, Rawal R. Anticancer effect of Moringa oleifera leaves extract against lung cancer cell line via induction of apoptosis. Advances in Cancer Biology - Metastasis. 2022;6:100072. doi:10.1016/j.adcanc.2022.100072https://hdl.handle.net/1805/41291Since ancient times, Moringa oleifera has been a common vegetable in many nations. It has a large number of phenolic compounds with a diverse range of biological activity. It has anticancer properties that can be exploited to create novel medications for the treatment of various malignancies. The current study was conducted to evaluate the in vitro anticancer activities of M. oleifera leaves extracts. The M. oleifera leaves extracts significantly inhibited cell proliferation in the human cancer cell line A549 in a dose-dependent manner. Morphological studies indicated that the extract of moringa leaves stimulated apoptosis as demonstrated by cell shrinkage, blebbing, chromatin condensation, and nuclear fragmentation. Quantitative RT-PCR analyses of Bax and Bcl-2 showed abnormal expression profiles of these genes under various treatment conditions. This study demonstrates that M. oleifera leaves may have the ability to suppress the growth of cancer cells while also enhancing human health and developing new food ingredients. The phytochemicals from M. oleifera leaves can be employed as the primary medications to cure cancer, according to in vitro studies.en-USAttribution 4.0 InternationalMoringa oleiferaAnticancer drugApoptosisLung cancerArticle