Stilger, Krista L.Sullivan, William J., Jr.2024-08-282024-08-282013Stilger KL, Sullivan WJ Jr. Elongator protein 3 (Elp3) lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii. J Biol Chem. 2013;288(35):25318-25329. doi:10.1074/jbc.M113.491373https://hdl.handle.net/1805/43009Background: Protein acetylation is prevalent in mitochondria, yet acetyltransferases mediating this activity are unknown. Results: Toxoplasma Elongator protein 3 (Elp3) possesses a unique C-terminal transmembrane domain necessary and sufficient to target it to the mitochondria. Conclusion: Elp3 is an essential tail-anchored mitochondrial acetyltransferase in Toxoplasma. Significance: Elp3 has conserved functions involving mitochondria that may predate its established role in transcription.en-USAttribution 4.0 InternationalIron-sulfur proteinMembrane enzymesMitochondriaParasitePost-translational modificationProtein targetingProtozoanApicomplexaElongatorAcetylationArticle