Kouri, Anne M.Andreoli, Sharon P.2017-06-072017-06-072017-03Kouri, A. M., & Andreoli, S. P. (2017). Clinical presentation and outcome of pediatric ANCA-associated glomerulonephritis. Pediatric Nephrology, 32(3), 449–455. https://doi.org/10.1007/s00467-016-3490-6https://hdl.handle.net/1805/12869Background Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a small- and medium-sized vasculitis classically seen in adult patients, with peak onset near the fifth to seventh decade of life. There is little data on ANCA-associated vasculitis in pediatric patients, and most studies have limited follow-up. Methods This is a retrospective chart review of 22 patients with ANCA-positive glomerulonephritis in a single institution from 1991 to 2013. Results Of the 22 patients, eight (36 %) required renal replacement therapy (RRT) at diagnosis; four of these patients recovered sufficient renal function to initially discontinue dialysis. Five patients (23 %) were treated with plasmapheresis at presentation. The median time from presentation until first clinical or serologic relapse was 1.7 ± 1.2 years. After a median follow-up of 5.8 years, just over half of our patients had chronic kidney disease (CKD) stages 1–3 (55 %). Seven (32 %) patients progressed to end-stage renal disease (ESRD) and eventually required kidney transplant. Conclusion ANCA-associated glomerulonephritis is a rare disorder in children. Presentation and outcomes vary significantly among patients. More research is required to follow these patients who are diagnosed in childhood to further characterize the long-term outcome of the disease.enPublisher PolicyANCA-positive glomerulonephritispediatric glomerulonephritisgranulomatosis with polyangiitisArticle