Ma, ShuoLi, XinchunWang, XinyueCheng, LiangLi, ZhongZhang, ChangzhengYe, ZhenlongQian, Qijun2020-01-092020-01-092019-09-07Ma, S., Li, X., Wang, X., Cheng, L., Li, Z., Zhang, C., … Qian, Q. (2019). Current Progress in CAR-T Cell Therapy for Solid Tumors. International journal of biological sciences, 15(12), 2548–2560. doi:10.7150/ijbs.34213https://hdl.handle.net/1805/21806Cancer immunotherapy by chimeric antigen receptor-modified T (CAR-T) cells has shown exhilarative clinical efficacy for hematological malignancies. Recently two CAR-T cell based therapeutics, Kymriah (Tisagenlecleucel) and Yescarta (Axicabtagene ciloleucel) approved by US FDA (US Food and Drug Administration) are now used for treatment of B cell acute lymphoblastic leukemia (B-ALL) and diffuse large B-cell lymphoma (DLBCL) respectively in the US. Despite the progresses made in treating hematological malignancies, challenges still remain for use of CAR-T cell therapy to treat solid tumors. In this landscape, most studies have primarily focused on improving CAR-T cells and overcoming the unfavorable effects of tumor microenvironment on solid tumors. To further understand the current status and trend for developing CAR-T cell based therapies for various solid tumors, this review emphasizes on CAR-T techniques, current obstacles, and strategies for application, as well as necessary companion diagnostics for treatment of solid tumors with CAR-T cells.en-USCAR-T cellsChimeric antigen receptorSolid tumorsCompanion diagnosticsCTCArticle