Singh, Ben S.Cazacu, Irina M.Deza, Carlos A.Rigaud, Bastien S.Saftoiu, AdrianGruionu, GabrielGuionu, LucianBrock, Kristy K.Koay, Eugene J.Herman, Joseph M.Bhutani, Manoop S.2023-10-022023-10-022022-12-19Singh BS, Cazacu IM, Deza CA, et al. Image Fusion Involving Real-Time Transabdominal or Endoscopic Ultrasound for Gastrointestinal Malignancies: Review of Current and Future Applications. Diagnostics (Basel). 2022;12(12):3218. Published 2022 Dec 19. doi:10.3390/diagnostics12123218https://hdl.handle.net/1805/35931Image fusion of CT, MRI, and PET with endoscopic ultrasound and transabdominal ultrasound can be promising for GI malignancies as it has the potential to allow for a more precise lesion characterization with higher accuracy in tumor detection, staging, and interventional/image guidance. We conducted a literature review to identify the current possibilities of real-time image fusion involving US with a focus on clinical applications in the management of GI malignancies. Liver applications have been the most extensively investigated, either in experimental or commercially available systems. Real-time US fusion imaging of the liver is gaining more acceptance as it enables further diagnosis and interventional therapy of focal liver lesions that are difficult to visualize using conventional B-mode ultrasound. Clinical studies on EUS guided image fusion, to date, are limited. EUS-CT image fusion allowed for easier navigation and profiling of the target tumor and/or surrounding anatomical structure. Image fusion techniques encompassing multiple imaging modalities appear to be feasible and have been observed to increase visualization accuracy during interventional and diagnostic applications.en-USAttribution 4.0 InternationalGI malignanciesEndoscopic ultrasoundImage fusionTransabdominal ultrasoundArticle