Ku, BonHeonLiu, JingNa, SungsooYokota, HirokiHong, ChinsukLim, HeeChang2025-05-142025-05-142025-04-16Ku B, Liu J, Na S, Yokota H, Hong C, Lim H. Effect of elastic modulus of tumour and non-tumour cells on vibration-induced behaviours. Sci Rep. 2025;15(1):13199. Published 2025 Apr 16. doi:10.1038/s41598-025-97837-zhttps://hdl.handle.net/1805/48120The mechanical behaviour of tumour and non-tumour cells under vibration remains insufficiently explored, particularly the role of elastic modulus in dynamic responses. This study investigates the vibration-induced mechanical behaviour in cellular structures with varying elastic moduli (E = 0.1 , 1 , and 10 kPa) and aspect ratios ([Formula: see text] and 4), focusing on vertical and horizontal forced vibrations. Finite element analysis was conducted to evaluate the natural frequencies, mode shapes, membrane accelerations, and stress responses. The intermediate aspect-ratio structures ([Formula: see text]) exhibited higher natural frequencies but a 64.2% increase in stress concentration, making them more susceptible to localised deformation under resonance. Conversely, higher aspect-ratio structures ([Formula: see text]) demonstrated improved vibrational stability with reduced resonance peaks and 64.6% lower localised stress. This study further confirmed that vertical vibrations generate higher stress and acceleration than horizontal vibrations owing to gravitational effects. Stress contour analysis indicated that under low-intensity vibrations, intermediate aspect-ratio structures may exceed their yield stress thresholds, leading to potential membrane rupture. These findings suggest that vibration-induced mechanical stimulation can be sensed differently depending on the elastic moduli and aspect ratios of tumour and non-tumour cells.en-USAttribution-NonCommercial-NoDerivatives 4.0 InternationalElastic modulusFinite element analysisForced vibration analysis methodLow-intensity vibrationsModal analysis methodTumour cell mechanicsVibration-induced stressArticle