Holmes, Jonathan M.Hercinovic, AmraMelia, B. MicheleLeske, David A.Hatt, Sarah R.Chandler, Danielle L.Dean, Trevano W.Kraker, Raymond T.Enyedi, Laura B.Wallace, David K.Mohney, Brian G.Cotter, Susan A.2021-05-042021-05-042021Holmes, J. M., Hercinovic, A., Melia, B. M., Leske, D. A., Hatt, S. R., Chandler, D. L., Dean, T. W., Kraker, R. T., Enyedi, L. B., Wallace, D. K., Mohney, B. G., & Cotter, S. A. (2021). Health-related quality of life in children with untreated intermittent exotropia and their parents. Journal of American Association for Pediatric Ophthalmology and Strabismus. https://doi.org/10.1016/j.jaapos.2020.10.011https://hdl.handle.net/1805/25876Purpose To determine whether health-related quality of life (HRQOL) scores improved or worsened over 3 years of observation in childhood intermittent exotropia without treatment. Methods A total of 111 children aged 3-11 years with intermittent exotropia were assigned to observation in a previously reported randomized trial comparing patching with observation. The intermittent exotropia questionnaire (IXTQ) was administered at baseline, 6 months, and 36 months. Rasch-calibrated IXTQ domain scores (Child, Proxy, Parent-psychosocial, Parent-function, and Parent-surgery) were compared between time points. The Child IXTQ was administered only to children ≥5 years of age (n = 78). Results Overall, Child IXTQ and Proxy IXTQ scores showed no significant change over 36 months (mean improvement from baseline to 36 months of 3.2 points [95% CI, −1.9 to 8.2] and −2.4 points [95% CI: −7.9 to 3.1], resp.). By contrast, Parent-psychosocial, Parent-function, and Parent-surgery domain scores all improved over 36 months (mean improvements of 12.8 points [95% CI, 5.9-19.6] and 14.2 points [95% CI, 8.0-20.3] and 18.5 points [95% CI, 9.7-27.3], resp.). Conclusions HRQOL of children with intermittent exotropia remains stable with observation over 3 years (by both child and proxy report), whereas parental HRQOL improves.enPublisher Policyhealth-related quality of lifeintermittent exotropiaobservation without treatmentArticle