Parashette, Kalyan RayWaseem, ShamailaHorn, DebraShah, AaliCroffie, Joseph2016-10-192016-10-192015-12Parashette, K. R., Waseem, S., Horn, D., Shah, A., & Croffie, J. (2015). Effect of Octreotide on Colonic Motility in Pediatric Patients With Chronic Recalcitrant Constipation. Journal of Pediatric Gastroenterology and Nutrition, 61(6), 626–629. http://doi.org/10.1097/MPG.0000000000000872https://hdl.handle.net/1805/11189Objective: The aim of the present study was to study the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders. Methods: This was a nonrandomized, single-center, open-label, prospective study evaluating the effect of a single subcutaneous dose of octreotide on colonic motility. Results: Thirteen patients (5 boys) were enrolled in the study. The age range was 4.6 to 16.2 years. Eleven patients (84%) had normal colonic manometry and 2 patients (16%) had colonic neuropathy. Motility Index (MI) (mmHg) for the 15 minutes before and after octreotide infusion was 6.03 ± 1.26 (95% confidence interval [CI] 5.35–6.72) and 5.32 ± 1.66 (95% CI 4.42–6.23), respectively, with P value of 0.08. MI for the 30 minutes before and after octreotide infusion was 6.89 ± 1.37 (95% CI 6.14–7.64) and 6.71 ± 1.47 (95% CI 5.91–7.52), respectively, with P value of 0.55. MI for the 45 minutes before and after octreotide infusion was 7.73 ± 1.32 (95% CI 7.01–8.45) and 7.53 ± 1.38 (95% CI 6.78–8.28), respectively, with P value of 0.8. Conclusion: Our study showed that the administration of octreotide resulted in no significant changes in colonic MI in pediatric patients with chronic recalcitrant constipation.enPublisher Policyconstipationoctreotidecolonic manometryArticle