Bavisotto, LindaKaushansk, KennethLin, NancyHromas, Robert2021-02-052021-02-051991-11-01Bavisotto, L., Kaushansky, K., Lin, N., & Hromas, R. (1991). Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro. The Journal of experimental medicine, 174(5), 1097-1101.https://hdl.handle.net/1805/25150Zinc finger proteins are transcriptional regulators of other genes, often controlling developmental cascades of gene expression. A recently cloned zinc finger gene, MZF-1, was found to be preferentially expressed in myeloid cells. Using complementary radiolabeled MZF-1 RNA hybridized to human bone marrow smears in situ, it was discovered that the expression of MZF-1 is essentially limited to the myelocyte and metamyelocyte stages of granulopoiesis. Antisense but not sense oligonucleotides from MZF-1 significantly inhibited granulocyte colony-stimulating factor-driven granulocyte colony formation in vitro.en-USAttribution 4.0 InternationalAntisense OligonucleotidesZinc Finger GeneIn VitroArticle