McBride, William J.Rodd, Zachary A.Bell, Richard L.Lumeng, LawrenceLi, Ting-Kai2016-02-292016-02-292014-05McBride, W. J., Rodd, Z. A., Bell, R. L., Lumeng, L., & Li, T.-K. (2014). The alcohol-preferring (P) and high-alcohol-drinking (HAD) rats – Animal Models of Alcoholism. Alcohol (Fayetteville, N.Y.), 48(3), 209–215. http://doi.org/10.1016/j.alcohol.2013.09.044https://hdl.handle.net/1805/8564The objective of this article is to review the literature on the utility of using the selectively bred alcohol-preferring (P) and high-alcohol-drinking (HAD) lines of rats in studies examining high alcohol drinking in adults and adolescents, craving-like behavior, and the co-abuse of alcohol with other drugs. The P line of rats meets all of the originally proposed criteria for a suitable animal model of alcoholism. In addition, the P rat exhibits high alcohol-seeking behavior, demonstrates an alcohol deprivation effect (ADE) under relapse drinking conditions, consumes amounts of ethanol during adolescence equivalent to those consumed in adulthood, and co-abuses ethanol and nicotine. The P line also exhibits excessive binge-like alcohol drinking, attaining blood alcohol concentrations (BACs) of 200 mg% on a daily basis. The HAD replicate lines of rats have not been as extensively studied as the P rats. The HAD1,2 rats satisfy several of the criteria for an animal model of alcoholism, e.g., these rats will voluntarily consume ethanol in a free-choice situation to produce BACs between 50–200 mg%. The HAD1,2 rats also exhibit an ADE under repeated relapse conditions, and will demonstrate similar levels of ethanol intake during adolescence as seen in adults. Overall, the P and HAD1,2 rats have characteristics attributed to an early onset alcoholic, and can be used to study various aspects of alcohol use disorders.en-USPublisher Policyalcohol-preferring (P) rathigh-alcohol-drinking (HAD) ratanimal model of alcoholismbinge drinkingalcohol-seeking behaviorArticle