Jiang, WeinaZhou, WeiUchida, HajimeKikumori, MasayukiIrie, KazuhiroWatanabe, RyuichiSuzuki, ToshiyukiSakamoto, BryanKamio, MichiyaNagai, Hiroshi2025-04-032025-04-032014-05-12Jiang W, Zhou W, Uchida H, et al. A new lyngbyatoxin from the Hawaiian cyanobacterium Moorea producens. Mar Drugs. 2014;12(5):2748-2759. Published 2014 May 12. doi:10.3390/md12052748https://hdl.handle.net/1805/46811Lyngbyatoxin A from the marine cyanobacterium Moorea producens (formerly Lyngbya majuscula) is known as the causative agent of "swimmer's itch" with its highly inflammatory effect. A new toxic compound was isolated along with lyngbyatoxin A from an ethyl acetate extract of M. producens collected from Hawaii. Analyses of HR-ESI-MS and NMR spectroscopies revealed the isolated compound had the same planar structure with that of lyngbyatoxin A. The results of optical rotation and CD spectra indicated that the compound was a new lyngbyatoxin A derivative, 12-epi-lyngbyatoxin A (1). While 12-epi-lyngbyatoxin A showed comparable toxicities with lyngbyatoxin A in cytotoxicity and crustacean lethality tests, it showed more than 100 times lower affinity for protein kinase Cδ (PKCδ) using the PKCδ-C1B peptide when compared to lyngbyatoxin A.en-USAttribution 4.0 InternationalLyngbyatoxin ACyanobacteriaMoorea producensToxicityProtein kinase CArticle