Bosslet, Gabriel T.Pollak, MicahJang, Jeong HoonRoll, RebekahSperling, MarkKhan, Babar2021-04-282021-04-282021Bosslet, G. T., Pollak, M., Jang, J. H., Roll, R., Sperling, M., & Khan, B. The effect of in-person primary and secondary school instruction on county-level SARS-CoV-2 spread in Indiana. Clinical Infectious Diseases. https://doi.org/10.1093/cid/ciab306https://hdl.handle.net/1805/25788Background To determine the county-level effect of in-person primary and secondary school reopening on daily cases of SARS-CoV-2 in Indiana. Methods This is a county-level population-based study using a panel data regression analysis of the proportion of in-person learning to evaluate an association with community-wide daily new SARS-CoV-2 cases. The study period was July 12-October 6, 2020. We included 73 out of 92 (79.3%) Indiana counties in the analysis, accounting for 85.7% of school corporations and 90.6% of student enrollement statewide. The primary exposure was the proportion of students returning to in-person instruction. The primary outcome was the daily new SARS-CoV-2 cases per 100,000 residents at the county level. Results There is a statistically significant relationship between the proportion of students attending K-12 schools in-person and the county level daily cases of SARS-CoV-2 28 days later. For all ages, the coefficient of interest (β) is estimated at 3.36 (95% CI: 1.91—4.81; p < 0.001). This coefficient represents the effect of a change the proportion of students attending in-person on new daily cases 28 days later. For example, a 10 percentage point increase in K-12 students attending school in-person is associated with a daily increase in SARS-CoV-2 cases in the county equal to 0.336 cases/100,000 residents of all ages. Conclusion In-person primary and secondary school is associated with a statistically significant but proportionally small increase in the spread of SARS-CoV-2 cases.enPublisher PolicyCOVID-19public healthschoolsArticle