Martin, Berdine R.McCabe, George P.McCabe, LindaJackson, George S.Horcajada, Marie NoelleOfford-Cavin, ElizabethPeacock, MunroWeaver, Connie M.2016-11-022016-11-022016-03Martin, B. R., McCabe, G. P., McCabe, L., Jackson, G. S., Horcajada, M. N., Offord-Cavin, E., … Weaver, C. M. (2016). Effect of Hesperidin With and Without a Calcium (Calcilock) Supplement on Bone Health in Postmenopausal Women. The Journal of Clinical Endocrinology & Metabolism, 101(3), 923–927. http://doi.org/10.1210/jc.2015-3767https://hdl.handle.net/1805/11320Context: Citrus fruits contain unique flavanones. One of the most abundant of the flavanones, hesperidin, has been shown to prevent bone loss in ovariectomized rats. Objective: The objective of the study was to measure the effect of hesperidin with or without calcium supplementation on bone calcium retention in postmenopausal women. Design: The study was a double-blind, placebo-controlled, randomized-order crossover design of 500 g hesperidin with or without 500 mg calcium supplement in 12 healthy postmenopausal women. Bone calcium retention was determined from urinary excretion of the rare isotope, 41Ca, from bone. Results: Calcium plus hesperidin, but not hesperidin alone, improved bone calcium retention by 5.5% (P < .04). Conclusion: Calcium supplementation (Calcilock), in combination with hesperidin, is effective at preserving bone in postmenopausal women. - See more at: http://press.endocrine.org/doi/10.1210/jc.2015-3767#sthash.ztalWWcv.dpufenPublisher Policyhesperidincitrus flavanonescalcium retentionArticle